Search on: PROCOLLAGEN N-ENDOPEPTIDASE 
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Descriptor English:   Procollagen N-Endopeptidase 
Descriptor Spanish:   Procolágeno N-Endopeptidasa 
Descriptor Portuguese:   Pró-Colágeno N-Endopeptidase 
Synonyms English:   Procollagen N Endopeptidase
Procollagen N Proteinase
Procollagen N-Proteinase
Procollagen Peptidase  
Tree Number:   D08.811.277.656.300.480.664
D08.811.277.656.675.374.664
Definition English:   An extracellular endopeptidase which excises a block of peptides at the amino terminal, nonhelical region of the procollagen molecule with the formation of collagen. Absence or deficiency of the enzyme causes accumulation of procollagen which results in the inherited connective tissue disorder--dermatosparaxis. EC 3.4.24.14. 
History Note English:   97; was PROCOLLAGEN PEPTIDASE 1977-96 (see under ENDOPEPTIDASES 1977-90) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   11784 
Unique Identifier:   D011348 

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